Trust AI has announced that Isaac OneHealth, its clinical AI platform developed specifically for dental practice, achieved a 100% score on a set of 324 of the most challenging questions from the United States Medical Licensing Examination (USMLE). This benchmark—originally established as a rigorous test of clinical reasoning by OpenEvidence in 2025—has now been reached by only two healthcare AI systems.
Although Isaac OneHealth is built for dentistry and has been validated in practice by more than 6,000 dentists, its performance on a medically oriented exam highlights its ability to handle complex, cross-disciplinary clinical scenarios. For dental professionals who routinely manage patients with significant medical comorbidities, polypharmacy, and systemic conditions, this type of reasoning capability provides potential support across both dental and medical domains.
"OpenEvidence pioneered this benchmark and showed what's possible when you build clinical AI the right way," said Dr. Bernard Casse, CEO and co-founder of Trust AI. "We have tremendous respect for what they've accomplished in medicine. What we've now demonstrated is that you can build clinical AI that achieves the same level of excellence — with the ability to work across specialties — in a capital-efficient way that makes this technology accessible to more areas of healthcare."
Trust AI emerged 4 months ago with the goal of improving how dental teams access clinical knowledge and make patient-care decisions. Isaac OneHealth’s adoption during private beta and public launch—through more than 6,000 dentists joining organically—reflects the platform’s early integration into clinical workflows.
According to the company, the USMLE evaluation was intended as a measure of clinical depth rather than a move into medical domains. "We wanted to know if the clinical intelligence we built for dentistry represented genuinely world-class healthcare AI," explained Dr. Divian Patel, co-founder and Chief Clinical Officer. "The USMLE is the gold standard for assessing clinical reasoning in medicine. Achieving 100% on the most challenging questions confirms that dentists using Isaac every day are working with AI that meets the highest standards in all of healthcare."
For clinicians already using the platform, the result echoes their day-to-day experience. The system is designed to assist with multidisciplinary considerations that commonly arise in dental care. "Dentists encounter patients with complex medical histories, drug interactions, and systemic conditions daily," explained Dr. Shervin Molayem, co-founder and Chief Innovation Officer. "Isaac's cross-domain reasoning means practitioners can confidently navigate these intersections with world-class support."
The platform’s growth has been largely organic, as dentists adopt the system for practical, point-of-care questions — from procedural guidance to medication considerations. For example, when clinicians request guidance for procedures such as a posterior superior alveolar nerve block, the platform provides structured steps, angulation guidance, and safety considerations relevant to real-world delivery.
Isaac’s underlying methodology blends three sources of clinical information: peer-reviewed academic literature, open-internet data reflecting practical clinical experience, and proprietary datasets supported by specialist feedback loops. The intent is to capture both evidence-based content and the applied judgment characteristic of experienced clinicians. "OpenEvidence has pioneered an exceptional academic-focused approach, training exclusively on medical journals like NEJM and JAMA," Dr. Casse explained. "We have deep respect for that rigor. Our philosophy is different: we believe the best clinical AI must combine academic literature with the practical wisdom that exists across the open internet and direct specialist feedback. Clinical excellence lives not just in published papers, but in the boots-on-the-ground experience shared by practitioners solving real-world problems every day."
Trust AI notes that this hybrid strategy aims to pair high performance on standardized benchmarks with clinically actionable support, while maintaining cost structures that make such tools broadly accessible.
While the USMLE benchmark speaks to Isaac’s foundational capabilities, the company emphasizes its continued focus on dental practice needs. An AI-native patient management system — spanning clinical decision support, insurance workflows, communication, diagnosis, and treatment planning — is currently in development.
"The USMLE result tells us our foundation is rock-solid," said Dr. Casse. "Now we're focused on what matters most: making every dentist more confident, every practice more efficient, and every patient better served."
